Hombre and I have killed a bunch of yotes through the years. when we started out one of us would have a .22 mag and the other had a .12ga with 00 buck. As we got more savvy and had more money he bought a AR15 and I bought a 25.06 but we always hunted together and one of us always has the .12ga. If you are hunting in much cover at all you will be surprised how often they just appear at 20 yards or so. The .12g works great for that. I think the main thing is how open it is where you hunt. With the .22mag we never really hunted anywhere we had more than a 75 or 100 yard shot and it usually worked fine they never went very far.