Well, I think some here are missing the point. I also love the .25-06, .270 and the .308, etc, etc, etc, but the question is, if there could be only ONE rifle, what would be the best caliber to be able to kill any big game animal in N. America? I will stand by the .30-06 as the best SINGLE rifle to own due to it's versatility, ammo availability and economical advantages. I seriously doubt your could pick a better caliber for an ONLY rifle.