The Anschutz 22 I have is left hand, but I tried to shoot a left hand Remington 870 once and it was odd to me. I've used a righty so much that the safety being for a lefty really screwed me up.

I checked out the Weatherby's on the web and they all have a "right palm swell" so that rules them out. It looks like it's going to be hard to beat the Ruger with the price difference and both of them coming in a lefty model. That is unless there is a big difference in quality between them and the Remingtons.